At a glance
ClinicalIndex Comparison Record- ✓Age 21–80 years
- ✓LDL cholesterol >120 mg/dL
- ✓Either diabetic or ≥3 components of metabolic syndrome (hypertension, fasting glucose >110 mg/dL, increased waist circumference, triglycerides >150 mg/dL, or low HDL)
- ✓Non-smoker
- ✕Age <21 or >80 years
- ✕Premenopausal females with potential for pregnancy
- ✕LDL cholesterol <120 mg/dL
- ✕On any oral antioxidants or lipid-lowering medications in the previous 8 weeks
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effect of Statins on Oxidative Stress and Endothelial Progenitor Cells: Comparison of Atorvastatin With Pravastatin
In Brief
A Phase 2 clinical trial evaluating Atorvastatin and Pravastatin for Diabetes Mellitus and 2 related conditions. Completed, enrolled 36 participants across 1 site.
Detailed Summary
Thirty-six subjects with hyperlipidemia and metabolic syndrome and/or diabetes were randomized in a double-blind manner to either pravastatin 80 mg or atorvastatin 10 mg daily. Oxidative stress (dROMs assay that measures lipid hydroperoxides, plasma thiobarbituric acid reactive substances \[TBARS\], and aminothiol levels) and brachial artery flow-mediated dilation (FMD) were measured at baseline and after 12 weeks of statin therapy.
Study Details
Timeline
Interventions
12 Weeks of Oral Atorvastatin 10 mg therapy.
12 Weeks of Oral Pravastatin 80 mg therapy.