At a glance
ClinicalIndex Comparison RecordNone specified.
- ✕Suicidal, psychotic, or bipolar depression
- ✕Alcohol or substance abuse
- ✕Regular use of mood-altering or vascular-function-altering medications (zolpidem, zaleplon, aspirin, NSAIDs, sympatholytics, theophylline, central-acting agonists, beta-blockers, coumadin, nitrates, benzodiazepines, steroids, tryptophan, MAOIs)
- ✕Narrow-angle glaucoma or liver disease
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Do Antidepressants Reverse the Effects of Early Life Stress on the Brain and Thrombovascular System and Improve Psychological, Neuroendocrine, and Platelet Function: A Study of Men and Women With Childhood Abuse.
In Brief
A Phase 4 clinical trial evaluating Escitalopram and Desipramine for Major Depressive Disorder. Completed, enrolled 40 participants across 1 site.
Detailed Summary
Men and women who have suffered sexual and/or physical abuse before the age of 12 are at increased risk for anxiety and mood disorders, other serious psychiatric disorders, and likely medical illnesses. What is not known is whether adult survivors of childhood adversity experience heightened negative emotions and increased physical responses due to altered norepinephrine or serotonin systems in their brains and bodies. The investigators expect to see that survivors of childhood adversity experience heightened negative emotions and increased physical responses to stress.
Study Details
Timeline
Interventions
10 mg of Escitalopram, and titrated up to 20 mg of Escitalopram after day 22 of intervention
25 mg of Desipramine for day 1-3, 50 mg of Desipramine for day 4-7, 75 mg of Desipramine for day 8-14, 100 mg of Desipramine for day 15-21. Titrated between 125 mg to 200 mg of Desipramine for day 22-56 of intervention