CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 319 enrolled
Drug / intervention
Escitalopram +2 moredrug
Likely dose
Escitalopram 10 mg daily for 6 weeks, then 20 mg daily for 16 weeksAI-extracted
Key inclusion· 6
  • ✓Unipolar major depression diagnosis
  • ✓HRSD (17-item) score ≥15
  • ✓English-speaking
  • ✓Willing to discontinue other psychotropic medications
Key exclusion· 6
  • ✕Lifetime bipolar disorder, schizophrenia, schizoaffective disorder, or psychotic disorder
  • ✕MMSE score ≤17
  • ✕Current or recent suicidal ideation/intent
  • ✕History of non-adherence in other Center protocols

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00177294
NCT00177294Phase 4Completed
CompareCT.gov

Geriatric Depression: Getting Better, Getting Well

University of Pittsburgh·interventional·Posted Sep 15, 2005·Updated Jan 12, 2012

In Brief

A Phase 4 clinical trial evaluating Escitalopram, Interpersonal Psychotherapy, and 1 other intervention for Depression. Completed, enrolled 319 participants across 1 site.

Detailed Summary

This study will determine whether adding interpersonal psychotherapy to treatment with the antidepressant escitalopram will be more effective in reducing symptoms of depression than antidepressant medication alone.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDepression
CountriesUnited States
CollaboratorsNational Institute of Mental Health (NIMH)

Timeline

Phase 4CompletedFinished
200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedSep 15, 2005
Enrollment StartApr 1, 2004
Primary CompletionAug 1, 2009
TodayJul 2, 2026
Enrollment to primary: 5.3 yearsPosted 20.8 years ago

Interventions

Escitalopramdrug

Escitalopram 10 mg daily for first 6 weeks, followed by escitalopram 20 mg daily for 16 additional weeks.

Interpersonal Psychotherapybehavioral

16 sessions of interpersonal psychotherapy (IPT)

Clinical Monitoringbehavioral

16 weeks of depression care management(DCM). No psychotherapy will be provided.