CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 220 enrolled
Drug / intervention
Escitalopram +4 moredrug
Likely dose
Escitalopram 10–20 mg daily, Venlafaxine 150–300 mg daily, or Duloxetine (dose not specified)AI-extracted
Key inclusion· 6
  • ✓Current episode of major depression
  • ✓HRS-D 17-item score of 15 or higher
  • ✓Able to speak English
  • ✓Willing to discontinue other psychotropic medications
Key exclusion· 6
  • ✕Meets DSM-IV criteria for bipolar disorder, schizophrenia, schizoaffective disorder, or psychotic disorders
  • ✕Alcohol or drug abuse within 12 months of study entry
  • ✕History of treatment non-adherence in other clinic protocols
  • ✕History of non-response to citalopram in other clinic protocols

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00177671
NCT00177671Phase 4Completed
CompareCT.gov

Maintenance Therapies in Late-Life Depression: MTLD III

University of Pittsburgh·interventional·Posted Sep 15, 2005·Updated Feb 6, 2013

In Brief

A Phase 4 clinical trial evaluating Escitalopram, Donepezil, and 3 other interventions for Depression and Dementia. Completed, enrolled 220 participants across 1 site.

Detailed Summary

This study will determine the effectiveness of combining escitalopram, venlafaxine, or duloxetine with donepezil, a medication used in Alzheimer's disease, in improving memory, concentration, attention, and problem solving abilities, and reducing the risk of depressive relapse in older individuals with depression.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDepression, Dementia
CountriesUnited States
CollaboratorsNational Institute of Mental Health (NIMH)

Timeline

Phase 4CompletedFinished
200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedSep 15, 2005
Enrollment StartDec 1, 2003
Primary CompletionSep 1, 2009
TodayJul 2, 2026
Enrollment to primary: 5.8 yearsPosted 20.8 years ago

Interventions

Escitalopramdrug

Escitalopram, 10mg to 20mg daily.

Donepezildrug

Donepezil, 5mg to 10mg daily.

Venlafaxinedrug

Venlafaxine, 150mg to 300mg daily.

Placebodrug

Duloxetinedrug