At a glance
ClinicalIndex Comparison Record- ✓Age 6 months to 17 years
- ✓Moderate to severe atopic dermatitis
- ✕Use of cephalexin or other antibiotic in the last 6 weeks
- ✕Allergy to cephalosporins
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Impact of Treating Staphylococcus Aureus Infection and Colonization on the Clinical Severity of Atopic Dermatitis
In Brief
A Phase 4 clinical trial evaluating Sodium hypochlorite (bleach) baths, Mupirocin ointment, and 2 other interventions for Atopic Dermatitis. Completed, enrolled 31 participants across 1 site.
Detailed Summary
Staphylococcus aureus (S. aureus) infection is perceived not only as a common secondary complication of atopic dermatitis (AD), but also as a culprit in the worsening of this condition. In addition, the recent development of community acquired methicillin-resistant S. aureus (CA-MRSA) has presented a new challenge to our management of AD, both in treatment of acute infections and maintenance therapy. The investigators would like to perform a randomized investigator-blinded placebo-controlled study of children aged 6 months to 17 years with moderate to severe atopic dermatitis with clinical signs of secondary bacterial infection to study: 1) the prevalence of CA-MRSA in our patient population; 2) the relationship of sensitivity of the S. aureus organism cultured from the infected lesion(s) to clinical response to oral cephalexin therapy and severity of the AD; and 3) whether concurrent treatment of S. aureus infection initially with nasal mupirocin ointment and sodium hypochlorite (bleach) baths can result in long-term S. aureus eradication and clinical stability.
Study Details
Timeline
Interventions
Sodium hypochlorite (bleach) baths twice weekly for 3 months
Intranasal mupirocin 2% ointment BID x five days (3 times total for subjects; one time only for family members)
Water baths twice weekly for three months
Intranasal petrolatum ointment twice daily for five days