At a glance
ClinicalIndex Comparison Record- ✓Diagnosis of severe asthma with one or both major criteria: continuous/near-continuous oral corticosteroids and/or high-dose inhaled steroids, plus two minor criteria
- ✓Age 18-60 years, both sexes
- ✓Post-bronchodilator FEV1 greater than 40% on day of bronchoscopy (for bronchoscopy procedures)
- ✓No asthma exacerbation within the past 4 weeks (for bronchoscopy procedures)
- ✕Pregnancy or unreliable contraception in women of childbearing age
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Inflammation and Corticosteroid Responsiveness in Severe Asthma
In Brief
An observational study for Asthma. Completed, enrolled 39 participants across 1 site.
Detailed Summary
Some patients with mild asthma may develop severe asthma. It is not known what makes patients with mild asthma become severe, and we plan to find out why this happens. Patients with severe asthma may have a different type of inflammation in the airway tubes. Patients with severe asthma do not get as much benefit from taking steroid inhalers or tablets compared to asthma patients with mild disease. The study hypothesis is that the inflammation in severe asthma is such that it makes steroids less effective in treating asthma. We will find out what possible abnormalities there are in the blood cells and the bronchoalveolar macrophage cells in the lungs of patients with severe asthma compared to those with mild or moderate asthma.