At a glance
ClinicalIndex Comparison RecordN/ACompleted· 192 enrolled
Drug / intervention
Magnesium Sulfate +1 moredrug
Likely dose
Magnesium Sulfate 4 gram bolus followed by 2 gm per hour infusion; or Nifedipine 10 mg sublingually every 20 minutes for three doses, followed by 20 mg orally every 4 or 6 hoursAI-extracted
Key inclusion· 1
- ✓Uterine contractions with cervical change or ruptured membranes in a preterm gestation
Key exclusion· 4
- ✕Placental abruption
- ✕Fetal distress
- ✕Placenta previa
- ✕Maternal medical contraindication to tocolysis
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Magnesium Sulfate Versus Nifedipine for the Acute Tocolysis of Preterm Labor: A Prospective, Randomized Trial
In Brief
A clinical study evaluating Magnesium Sulfate and Nifedipine for Obstetric Labor, Premature. Completed, enrolled 192 participants across 1 site.
Detailed Summary
To compare intravenous magnesium sulfate to oral nifedipine for acute tocolysis of preterm labor
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsObstetric Labor, Premature
CountriesUnited States
Collaborators--
Timeline
N/ACompletedFinished
19992000200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
Enrollment StartApr 1999
Primary CompletionJul 2005
First PostedSep 2005
Study CompletionJul 2007
TodayJul 2026
First PostedSep 16, 2005
Enrollment StartApr 1, 1999
Primary CompletionJul 1, 2005
Study CompletionJul 1, 2007
TodayJul 2, 2026
Enrollment to primary: 6.3 yearsPosted 20.8 years ago
Interventions
Magnesium Sulfatedrug
Preterm labor treatment with Magnesium Sulfate 4 gram bolus followed by 2 gm per hour infusion. 2 Gm bolus as needed and/or rate increase up to 4gm per hour were allowed at the discretion of the treating physician.
Nifedipinedrug
Preterm labor treatment with Nifedipine 10 mg. sublingually every 20 minutes for three doses, followed by 20 mg. orally every 4 or 6 hours.