CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 20 enrolled
Drug / intervention
bupropion and smoking cessation behavioral interventiondrug
Likely dose
Bupropion (dose not specified in trial record) with smoking cessation behavioral interventionAI-extracted
Key inclusion· 3
  • ✓Age at least 18 years old
  • ✓Smoking at least 10 cigarettes per day (≥1/2 pack)
  • ✓Meets DSM-IV criteria for major depressive episode
Key exclusion· 13
  • ✕Current pregnancy or breastfeeding
  • ✕History of seizures, seizure disorder, significant head trauma, or CNS tumor
  • ✕Family history of seizures
  • ✕Current diagnosis of seizure disorder, liver disease, kidney disease, congestive heart failure, or diabetes mellitus

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00186446
NCT00186446Phase 4Completed
CompareCT.gov

Treatment of Nicotine Dependence and Acute Depression

Stanford University·interventional·Posted Sep 16, 2005·Updated Apr 4, 2017

In Brief

A Phase 4 clinical trial evaluating bupropion and smoking cessation behavioral intervention for Major Depressive Disorder and Nicotine Dependence. Completed, enrolled 20 participants across 1 site.

Detailed Summary

The purpose of this study is to assess the safety and feasibility of concurrent treatment of nicotine dependence (cigarette smoking) and acute depression. Participants who meet DSM-IV criteria for both nicotine dependence and acute major depression will be given pharmacological treatment for both disorders at the same time, along with a brief behavioral intervention for smoking cessation.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMajor Depressive Disorder, Nicotine Dependence
CountriesUnited States
CollaboratorsGlaxoSmithKline

Timeline

Phase 4CompletedFinished
200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedSep 16, 2005
Enrollment StartJun 1, 2004
Primary CompletionSep 1, 2007
TodayJul 2, 2026
Enrollment to primary: 3.3 yearsPosted 20.8 years ago

Interventions

bupropion and smoking cessation behavioral interventiondrug