CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 49 enrolled
Drug / intervention
Cyclophosphamide, Fludarabine, Clofarabine, Etoposide, Interleukin-2 +2 moredrug
Likely dose
Not stated in record
Key inclusion· 3
  • ✓AML in complete remission, relapsed/refractory, or with increasing minimal residual disease
  • ✓Recovered from toxicity of previous therapy with evidence of bone marrow recovery (for CR patients)
  • ✓If prior stem cell transplant, ≥60 days must have elapsed and no evidence of GVHD
Key exclusion· 2
  • ✕Pregnant status
  • ✕Inadequate renal, liver, or pulmonary function

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00187096
NCT00187096N/ACompleted
CompareCT.gov

Pilot Study Of Haplo-Identical Natural Killer Cell Transplantation For Acute Myeloid Leukemia

St. Jude Children's Research Hospital·interventional·Posted Sep 16, 2005·Updated Jun 19, 2014

In Brief

A clinical study evaluating Cyclophosphamide, Fludarabine, Clofarabine, Etoposide, Interleukin-2, Natural Killer Cell Infusion, and 1 other intervention for Acute Myeloid Leukemia. Completed, enrolled 49 participants across 1 site.

Detailed Summary

The purpose of this study is to assess the safety and efficacy of infusing natural killer cells from a donor as treatment for patients with acute myeloid leukemia in remission or who have experienced relapse.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsAcute Myeloid Leukemia
CountriesUnited States
Collaborators--

Timeline

N/ACompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedSep 16, 2005
Enrollment StartSep 1, 2005
Primary CompletionFeb 1, 2012
Study CompletionMar 1, 2013
TodayJul 2, 2026
Enrollment to primary: 6.4 yearsPosted 20.8 years ago

Interventions

Cyclophosphamide, Fludarabine, Clofarabine, Etoposide, Interleukin-2drug

See Detailed Description section for additional details of treatment interventions.

Natural Killer Cell Infusionprocedure

See Detailed Description section for additional details of treatment interventions.

CliniMACS Systemdevice

See Detailed Description section for additional details of treatment interventions.