At a glance
ClinicalIndex Comparison Record- ✓Age at least 8 months and at most 25 years at time of irradiation
- ✓Histologically confirmed craniopharyngioma, ependymoma, low-grade astrocytoma, or high-grade glioma (or radiographically diagnosed craniopharyngioma/low-grade glioma in selected patients)
- ✓Tumor type requires only focal irradiation
- ✓No prior fractionated external beam radiation therapy
None specified.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Phase II Study of Image-Guided Radiation Therapy for Pediatric CNS Tumors and Quantification of Radiation-Related CNS Effects
In Brief
A Phase 2 clinical trial evaluating Radiation Therapy for Central Nervous System Tumors and Brain Tumors. Completed, enrolled 361 participants across 1 site.
Detailed Summary
The purpose of the study was to determine if treating a limited volume of normal tissue surrounding the tumor or tumor bed using conformal radiation therapy would achieve similar rates of disease control compared to standard radiation therapy. The study was also conducted to examine the effect of irradiation on neurological, endocrine and cognitive function.
Study Details
Timeline
Interventions
External Beam Radiation Therapy: 54Gy administered at 1.8Gy per day for low-grade glioma, craniopharyngioma and selected ependymoma.
External Beam Radiation Therapy: 59.4Gy administered at 1.8Gy per day for high-grade glioma and selected ependymoma.