At a glance
ClinicalIndex Comparison RecordPhase 4Completed· 1,858 enrolled
Drug / intervention
Multiple vs. single courses of antenatalcorticosteroidsdrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Multiple Courses of Antenatal Corticosteroids for Preterm Birth Study (MACS)
In Brief
A Phase 4 clinical trial evaluating Multiple vs. single courses of antenatalcorticosteroids for Pregnancies at Increased Risk of Preterm Birth. Completed, enrolled 1,858 participants across 1 site.
Detailed Summary
In women at 26 to 30 weeks gestation and who are risk for threatened early birth, who have not had their baby by 14 or more days after being given a single course of antenatal corticosteroids (ACS), do repeated courses of ACS every 14 days until 33 weeks' gestational age lower the risk of illness or death in babies compared to repeated courses of placebo. Children are assessed at 2 years and 5 years for neurodevelopmental impairment.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesCanada
Collaborators--
Timeline
Phase 4CompletedFinished
200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
Enrollment StartApr 2001
First PostedSep 2005
Primary CompletionJun 2007
Study CompletionDec 2011
TodayJul 2026
First PostedSep 16, 2005
Enrollment StartApr 1, 2001
Primary CompletionJun 1, 2007
Study CompletionDec 1, 2011
TodayJul 2, 2026
Enrollment to primary: 6.2 yearsPosted 20.8 years ago
Interventions
Multiple vs. single courses of antenatalcorticosteroidsdrug