CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 60 enrolled
Drug / intervention
Irinotecan +3 moredrug
Likely dose
Irinotecan 50 mg/m² days 1 & 8 each cycle; Carboplatin AUC 5; Bevacizumab 10 mg/kg IV every 2 weeks for 10 doses starting week 16AI-extracted
Key inclusion· 6
  • ✓Histologically or cytologically confirmed small cell lung cancer
  • ✓Limited stage disease documented by standard staging evaluation
  • ✓Measurable or evaluable disease
  • ✓No prior chemotherapy, radiation therapy, or biologic therapy
Key exclusion· 12
  • ✕Age less than 18 years
  • ✕History of other malignancies
  • ✕Pregnancy or lactation
  • ✕CNS metastases or leptomeningeal disease

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00193375
NCT00193375Phase 2Completed
CompareCT.gov

Phase II Trial of Concurrent Irinotecan, Carboplatin and Radiation Therapy Followed by Bevacizumab (Avastin) in the Treatment of Patients With Limited Stage Small Cell Lung Cancer

SCRI Development Innovations, LLC·interventional·Posted Sep 19, 2005·Updated Aug 10, 2016

In Brief

A Phase 2 clinical trial evaluating Irinotecan, Carboplatin, and 2 other interventions for Lung Cancer. Completed, enrolled 60 participants.

Detailed Summary

In this multicenter trial, we plan to evaluate the feasibility and toxicity of initial treatment with irinotecan/carboplatin/radiation therapy, followed by treatment with bevacizumab, in patients with limited stage small cell lung cancer.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsLung Cancer
Countries--
CollaboratorsGenentech, Inc., Pharmacia and Upjohn

Timeline

Phase 2CompletedFinished
2003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedSep 19, 2005
Enrollment StartAug 1, 2003
Primary CompletionApr 1, 2008
Study CompletionMay 1, 2008
TodayJul 2, 2026
Enrollment to primary: 4.7 yearsPosted 20.8 years ago

Interventions

Irinotecandrug

50mg/m2 days 1 \& 8 each 21-day cycle 1 \& 2, 28-day cycle 3 \& 4

Carboplatindrug

AUC 5

Bevacizumabdrug

10mg/kg IV every 2 weeks for 10 doses starting week 16

Radiationradiation