At a glance
ClinicalIndex Comparison Record- ✓Age older than 18 years
- ✓Current opioid treatment for more than 1 month
- ✓Scheduled to undergo vertebroplasty with general anesthesia
None specified.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Effects of Intraoperative Nitrous Oxide on Postoperative Pain for Patients With Current Opioid Treatment After Vertebroplasty.
In Brief
A Phase 2 clinical trial evaluating Air and Protox for Chronic Pain. Completed, enrolled 39 participants across 1 site.
Detailed Summary
Peroperative opioids are known to induce N-Methyl-D-Aspartate dependent enhancement of postoperative hyperalgesia. For patients with current opioid treatment, these phenomena could be exagerated and could produce greater postoperative opioid consumption and higher pain score. Since Nitrous oxide has anti- N-Methyl-D-Aspartate properties, the aim of this study was to evaluate, in patients with current opioid treatment, the effects of peroperative Nitous oxide on postoperative opioid consumption and pain score, after vertebroplasty.
Study Details
Timeline
Interventions
Patients undergo long-term morphine treatment and vertebral cementoplasty. During the procedure, patients are ventilated with a mixture of air and oxygen.
Patients undergo long-term morphine treatment and vertebral cementoplasty. During the procedure, patients are ventilated with a mixture of oxygen and nitrous oxide.