CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 221 enrolled
Drug / intervention
Fixed lower-energy defibrillation +1 moreprocedure
Likely dose
Fixed 150 J per shock vs escalating 200 J, 300 J, then 360 J per shockAI-extracted
Key inclusion· 3
  • ✓Witnessed out-of-hospital cardiac arrest
  • ✓Requiring defibrillation
  • ✓First responder treatment with automated external defibrillator
Key exclusion· 5
  • ✕Terminal illness or do-not-resuscitate (DNR) status
  • ✕CPR duration less than 10 minutes
  • ✕Acute trauma
  • ✕Exsanguination

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00212992
NCT00212992Phase 3Completed
CompareCT.gov

A Pilot Randomized Controlled Trial to Compare Fixed Versus Escalating Energy Regimens for Biphasic Waveform Defibrillation

Ottawa Hospital Research Institute·interventional·Posted Sep 21, 2005·Updated Apr 25, 2025

In Brief

A Phase 3 clinical trial evaluating Fixed lower-energy defibrillation and Escalating higher-energy defibrillation for Cardiac Arrest. Completed, enrolled 221 participants across 1 site.

Detailed Summary

This study will compare the effect of constant low-level energy \[150 joules\] to an escalating energy \[200-300-360 joules\] regimen of biphasic waveform defibrillation on multiple patient outcomes.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCardiac Arrest
CountriesCanada
Collaborators--

Timeline

Phase 3CompletedFinished
200120022003200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedSep 21, 2005
Enrollment StartMar 1, 2001
Primary CompletionSep 1, 2005
Study CompletionJul 1, 2006
TodayJul 2, 2026
Enrollment to primary: 4.5 yearsPosted 20.8 years ago

Interventions

Fixed lower-energy defibrillationprocedure

Every shock administered at 150 J

Escalating higher-energy defibrillationprocedure

First shock administered at 200 J, second shock at 300 J, all subsequent shocks at 360 J