At a glance
ClinicalIndex Comparison RecordPhase 4Completed· 63 enrolled
Drug / intervention
Dexamethasone +1 moredrug
Likely dose
Dexamethasone 8 mg orally, single doseAI-extracted
Key inclusion· 3
- ✓Age >17 years
- ✓Physician-diagnosed migraine treated in the ED
- ✓Willing and able to be contacted for follow-up between 48-72 hours after discharge
Key exclusion· 8
- ✕Pregnancy
- ✕Allergy to study medication
- ✕Findings inconsistent with migraine
- ✕Requiring hospital admission for further investigation and treatment
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Does a Single Oral Dose of Dexamethasone After Successful Emergency Treatment of Migraine Reduce the Incidence or Severity of Rebound Headache Within 48 Hours?
The Joseph Epstein Centre for Emergency Medicine Research·interventional·Posted Sep 22, 2005·Updated Apr 30, 2015
In Brief
A Phase 4 clinical trial evaluating Dexamethasone and placebo for Migraine. Completed, enrolled 63 participants across 1 site.
Detailed Summary
The aim of this project is to determine if a single dose of oral dexamethasone at the time of discharge from the emergency department (ED) \[after successful treatment\] prevents rebound headache. Hypothesis: That single dose oral dexamethasone 8mg reduces the proportion of patients who suffer rebound headache after treatment for migraine in the ED.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMigraine
CountriesAustralia
Collaborators--
Timeline
Phase 4CompletedFinished
20052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
Enrollment StartApr 2005
First PostedSep 2005
Primary CompletionDec 2006
Study CompletionJul 2007
TodayJul 2026
First PostedSep 22, 2005
Enrollment StartApr 1, 2005
Primary CompletionDec 1, 2006
Study CompletionJul 1, 2007
TodayJul 2, 2026
Enrollment to primary: 1.7 yearsPosted 20.8 years ago
Interventions
Dexamethasonedrug
Single dose oral dexamethasone 8mg at time of ED discharge
placebodrug
Single dose oral placebo at ED discharge