At a glance
ClinicalIndex Comparison Record- ✓Meets SCID criteria for cocaine abuse or dependence
- ✓In general good health
- ✓HIV-positive participants allowed if in good health and no medication interactions
- ✕Meets diagnostic criteria for other psychiatric disorders or drug dependence (except nicotine)
- ✕Current cardiovascular disease as determined by electrocardiogram
- ✕On probation or parole if circumstances do not allow study completion or confidentiality cannot be maintained
- ✕Previously received treatment with d-amphetamine, modafinil, or aripiprazole
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Pharmacotherapy Dosing Regimen (Cocaine Dependence Population)
In Brief
A Phase 2 clinical trial evaluating D-Amphetamine 30mg, D-Amphetamine 60mg, and 4 other interventions for Cocaine-Related Disorders. Completed, enrolled 73 participants across 1 site.
Detailed Summary
Cocaine dependence is a major public health problem; an effective primary treatment for cocaine dependent individuals has yet to be found. The purpose of this study is to examine the effects of d-amphetamine and modafinil, when given alone and in combination, in treating cocaine dependent individuals.
Study Details
Timeline
Interventions
Manual-based, cognitive-behavioral therapy was provided for 1 hour each week by master's-level therapists. The cognitive-behavioral therapy emphasized relapse prevention and coping skills.