At a glance
ClinicalIndex Comparison RecordN/ACompleted· 105 enrolled
Drug / intervention
Paroxetine +1 moredrug
Likely dose
Paroxetine 10 mg for 1 week followed by 20 mg for 3 weeksAI-extracted
Key inclusion· 1
- ✓Smokes at least 10 cigarettes per day on average during the year prior to enrollment
Key exclusion· 9
- ✕Interested in quitting smoking within 3 months following enrollment
- ✕Current unstable medical condition
- ✕Substance abuse within the year prior to enrollment
- ✕Current use of medications that interfere with study measures or would interact with paroxetine, including CYP2D6 substrates and psychoactive medications
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Smoking, Antidepressants, and Response to Mental Stress
In Brief
A clinical study evaluating Paroxetine and Placebo for Tobacco Use Disorder. Completed, enrolled 105 participants across 1 site.
Detailed Summary
Smokers report that they often smoke cigarettes during stressful times. The combined effect of smoking and exposure to stress leads to exaggerated increases in blood pressure, heart rate and other measures of stress response. This combination may result in greater cardiovascular harm than either smoking or stress alone. The purpose of this study is to determine the effects of paroxetine on the response to stress after smoking.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsTobacco Use Disorder
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)
Timeline
N/ACompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedSep 2005
Enrollment StartOct 2005
Primary CompletionAug 2010
TodayJul 2026
First PostedSep 22, 2005
Enrollment StartOct 1, 2005
Primary CompletionAug 1, 2010
TodayJul 2, 2026
Enrollment to primary: 4.8 yearsPosted 20.8 years ago
Interventions
Paroxetinedrug
10 mg for 1 week followed by 20 mg for 3 weeks
Placebodrug