At a glance
ClinicalIndex Comparison Record- ✓Meets DSM-IV criteria for cocaine dependence
- ✓Meets DSM-IV criteria for adult ADHD
- ✓Cocaine is the primary drug of abuse
- ✕Current major depression or other Axis I psychiatric disorders requiring psychiatric intervention (except ADHD or substance abuse)
- ✕Unstable physical disorders including uncontrolled hypertension (SBP >150, DBP >90) or tachycardia (HR >100)
- ✕Acute hepatitis (chronic mild elevation <2–3× normal limit allowed)
- ✕Diabetes
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Atomoxetine Treatment for Cocaine Abuse and Adult Attention-Deficit Hyperactivity Disorder (ADHD): A Preliminary Open Trial
In Brief
A Phase 2 clinical trial evaluating Atomoxetine for Attention Deficit Disorder With Hyperactivity and Cocaine-Related Disorders. Completed, enrolled 20 participants across 1 site.
Detailed Summary
Studies have shown that individuals with attention deficit hyperactivity disorder (ADHD) are at greater risk for having a substance use disorder compared to people who do not have ADHD. Rates of cocaine abuse in adults with ADHD are significantly higher than they are in adults who do not have ADHD. Some clinicians suggest that adults with ADHD may abuse cocaine in order to self-medicate their ADHD symptoms. Atomoxetine is a drug that has been effective in treating ADHD. This study will evaluate the effectiveness of atomoxetine in reducing cocaine use in people with ADHD who abuse cocaine.
Study Details
Timeline
Interventions
At the start of week 7, patients will be maintained at 80 mg/day or increased to the maximal dose of 100 mg/day if less than a 50% reduction of symptoms on the ADHD Rating Scale occurs, and if the patient is tolerating the medication well.