At a glance
ClinicalIndex Comparison Record- ✓HIV seropositive
- ✓Currently enrolled in methadone maintenance treatment for at least one month
- ✓Current major or subsyndromal depression (subsyndromal = major depression without full diagnostic criteria but CGI-S of 2 [mildly ill])
- ✓Prescribed antiretroviral therapy for HIV and under care of a primary care provider
- ✕Active untreated, unstable major mental illness (untreated psychosis or mania)
- ✕Other Axis I psychiatric disorders (besides depression) that would interfere with ability to participate (CGI-S >6)
- ✕Unable or unwilling to provide informed consent
- ✕Currently in cognitive behavioral therapy for depression
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
CBT for Depression & Adherence in HIV Methadone Patients
In Brief
A clinical study evaluating CBT-AD and ETAU for Adherence and 5 related conditions. Completed, enrolled 89 participants across 1 site.
Detailed Summary
Patients with HIV, depression, and opioid-dependence are at high risk for poor health outcomes. This is a two-arm randomized controlled trial of cognitive-behavioral therapy for depression and HIV medication adherence in patients with opioid dependence who are receiving methadone maintenance treatment. The project is based on our pilot work with close attention to NIDA guidelines for a staged approach to treatment development and testing (Rounsaville et al., 2001). Depression is highly comorbid with both HIV infection and with opioid dependence. Depression and substance abuse are both associated with poor adherence to antiretroviral medications. Patients with HIV, depression, and opioid dependence are at high risk for poor health outcomes. Cognitive-behavioral therapy is the most widely studied and efficacious psychosocial intervention for depression; and research by the PI and others has shown that cognitive-behavioral interventions have been successful in promoting adherence to HIV medications.
Study Details
Timeline
Interventions
Cognitive behavioral therapy for adherence and depression consisting of 1 session focusing on adherence and 8 sessions consisting of cognitive behavioral therapy for medication adherence and depression.
Enhanced treatment as usual consisting of 1 session focused on adherence (the same session as the CBT-AD intervention) and 8 sessions for participants to complete self-reports and collect adherence data.