At a glance
ClinicalIndex Comparison Record- ✓Current corticosteroid use of 7 mg or more daily for at least 6 months
- ✓Age 18-65 years
- ✕Currently taking Depakote (valproate)
- ✕Currently taking Rifampin
- ✕Diagnosis of major depressive disorder, schizophrenia, PTSD, or bipolar I/II disorder not related to corticosteroid use
- ✕Diseases with CNS involvement
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Clinical Trial of Lamotrigine to Reverse Cognitive Impairment in Chronic Corticosteroid-Treated Patients
In Brief
A Phase 4 clinical trial evaluating Lamotrigine (Drug) for Memory Impairment Due to Corticosteroid Use and 2 related conditions. Completed, enrolled 28 participants across 1 site.
Detailed Summary
The purpose of this study is to determine if lamotrigine therapy is associated with improvement in mood, memory and hippocampal size and function in patients receiving chronic corticosteroid therapy. Standard care for mood changes associated with corticosteroid therapy, if severe, includes antidepressants or other medications which can influence mood. No therapies, other than dose reduction or discontinuation, are currently available for memory loss associated with corticosteroid treatment. However, very little information is available on the treatment of either mood or memory changes associated with corticosteroid treatment, thus the proposed project may improve standard care.