At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Evaluation and Treatment of Autonomic Failure.
In Brief
A Phase 1 clinical trial evaluating Atomoxetine, Acarbose, and 23 other interventions for Autonomic Failure and Orthostatic Hypotension. Completed, enrolled 389 participants across 1 site.
Detailed Summary
The autonomic nervous system serves multiple regulatory functions in the body, including the regulation of blood pressure and heart rate, gut motility, sweating and sexual function. There are several diseases characterized by abnormal function of the autonomic nervous system. Medications can also alter autonomic function. Impairment of the autonomic nervous system by diseases or drugs may lead to several symptoms, including blood pressure problems (e.g., high blood pressure lying down and low blood pressure on standing), sweating abnormalities, constipation or diarrhea and sexual dysfunction. Because treatment options for these patients are limited. We propose to study patients autonomic failure and low blood pressure upon standing and determine the cause of their disease by history and examination and their response to autonomic testing which have already been standardized in our laboratory. Based on their possible cause, we will tests different medications that may alleviate their symptoms.
Study Details
Timeline
Interventions
10-50 mg, PO. Single dose. Alone or in combination with Yohimbine or Mestinon.
25-100 mg, PO. Single dose.
30 mg-180 mg PO. Single dose. Alone or in combination with Yohimbine or atomoxetine.
2.7, 5.4 or 10.8 mg PO. Single dose. Alone or in combination with Atomoxetine or Pyridostigmine.
2.5, 5.0, 7.5, 10 mg PO. Single dose
PO.Single dose.
50-400 mg PO. Single dose
5-50 µg, S.C. Single dose.
Tap water 2 onz., 8 oz., 16 oz. PO, alone or in combination with any of the above medications. Single dose.
12.5 mg-100 mg PO. Single dose. Alone or in combination with Ranitidine
150-300 mg PO. Single dose. Alone or in combination with Diphenhydramine.
5 - 40 mg PO. Single dose
Ergotamine: 1.0 mg PO. Single dose. Caffeine 100 mg PO.Single dose
50-200 mg PO. Single dose
15, 30 or 60 mg, PO. Single dose.
5 or 10 mg PO. Single dose.
25, 50 or 75 mg, PO. Singe dose.
300, 600 or 900 mg, PO. Single dose.
1-2 sprays/ nostril. Single dose.
6-10 g, PO. Single dose.
125-1000 mg PO. Single dose. Alone or in combination with yohimbine or midodrine
1.5-6 mg PO. Single dose.
10mg/100mg or 25mg/100mg. 1-2 tab PO. Single dose. Alone or in combination with carbidopa (Lodosyn) 25-175 mg
External abdominal compression (20-40 mm Hg) with an inflatable abdominal binder applied after a pressor agent (e.g. midodrine, yohimbine).
External abdominal compression (5 mm Hg) with an inflatable abdominal binder applied after a pressor agent (e.g. midodrine, yohimbine).