At a glance
ClinicalIndex Comparison Record- ✓Diagnosis of schizophrenia, schizoaffective disorder, or schizophreniform disorder
- ✓Ages 18–50
- ✓BPRS total score >40 AND CGI >4 (moderately ill) and/or intolerant to current antipsychotic
- ✕Prior treatment with ziprasidone
- ✕Medical condition that contraindicates ziprasidone treatment
- ✕Depot antipsychotic medication within past 3 months
- ✕Current alcohol or psychoactive substance dependence
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Neurocognitive Effects of Ziprasidone: Relationship to Working Memory and Dopamine Blockade
In Brief
A clinical study evaluating ziprasidone vs risperidone or olanzapine for Schizophrenia. Completed, enrolled 35 participants across 1 site.
Detailed Summary
Ziprasidone is a newer drug intended for the treatment of the symptoms of schizophrenia. This new drug may have an added benefit of being able to help with some of the difficulties in problem solving and memory that many patients with schizophrenia experience. The present study wants to look at ziprasidone and two other drugs frequently used to treat the symptoms of schizophrenia (risperidone and olanzapine) to see if problem solving and memory get better with ziprasidone treatment. Moreover, we will look at symptoms and how they change with treatment.
Study Details
Timeline
Interventions
ziprasidone target dose is 160 mg/day risperidone target dose is 4 mg/day olanzapine target dose is 20 mg/day