At a glance
ClinicalIndex Comparison Record- ✓At least 18 years of age
- ✓Reporting daily hot flashes
- ✓Postmenopausal (>12 months amenorrhea) to limit sample variability
- ✓1 month to 5 years post-treatment (surgery, radiation, chemotherapy) for non-metastatic breast cancer
- ✕Current depression
- ✕History of migraines
- ✕History of hepatitis
- ✕Abnormal chemistry profile (e.g., sodium, potassium, glucose)
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Role of Serotonin in Hot Flashes After Breast Cancer
In Brief
A clinical study evaluating Acute tryptophan depletion and Half-strength tryptophan depletion (Control) for Breast Cancer. Completed, enrolled 28 participants across 1 site.
Detailed Summary
The purpose of this proposal is to improve our understanding of the role of tryptophan and serotonin in hot flashes. The main hypothesis is that alterations in tryptophan and serotonin levels are involved in the induction of hot flashes in women with breast cancer and genetic variations in the serotonin receptors and transporters also play a role.
Study Details
Timeline
Interventions
L-alanine (5.5g), L-arginine (4.9g), L-cysteine (2.7g), glycine (3.2g), L-histidine (3.2g), L-isoleucine (8.0g), L-leucine (13.5g), L-lysine (11.0g), L-methionine (3.0g), L-phenylalanine (5.7g), L-proline (12.2g), L-serine (6.9g), L-threonine (6.9g), L-tyrosine (6.9g), L-valine (8.9g)
L-alanine (1.4g), L-arginine (1.2g), L-cysteine (0.7g), glycine (0.8g), L-histidine (0.8g), L-isoleucine (2.0g), L-leucine (3.4g), L-lysine (2.8g), L-methionine (0.8g), L-phenylalanine (1.4g), L-proline (3.1g), L-serine (1.7g), L-threonine (1.7g), L-tyrosine (1.7g), L-valine (2.2g), and fillers (7.95g).