CI

At a glance

ClinicalIndex Comparison Record
N/ACompleted· 252 enrolled
Drug / intervention
20 mcg ethinyl estradiol and 100 mcg levonorgestrel +2 moredrug
Likely dose
Ethinyl estradiol 20 mcg and levonorgestrel 100 mcg daily for 6 months (oral contraceptive arm)AI-extracted
Key inclusion· 3
  • Confirmed TMD pain diagnosis from enrollment exam at University of Washington
  • Menstruates on a regular basis
  • Not planning pregnancy in next 6 months
Key exclusion· 4
  • History of drug or alcohol abuse
  • Current smoker aged 35 or older at any time during study
  • Lives >1 hour driving distance from University of Washington Seattle campus
  • Psychiatric disability

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00237042
NCT00237042N/ACompleted

Hormonal Cycles in Women: Effects on TMD Pain & Symptoms

University of Washington·interventional·Posted Oct 12, 2005·Updated Jul 11, 2011

In Brief

A clinical study evaluating Self Management, Targeted Self Management, and 1 other intervention for Temporomandibular Joint Disorders. Completed, enrolled 252 participants across 1 site.

Detailed Summary

The purpose of this study is to determine whether treatments targeted to the hormonal factors and the cyclicity of TMD symptoms associated with the menstrual cycle are more effective in relieving TMD pain and symptoms than standard self management treatment.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
CountriesUnited States

Timeline

N/ACompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedOct 12, 2005
Enrollment StartOct 1, 2005
Primary CompletionJun 1, 2010
TodayJul 2, 2026
Enrollment to primary: 4.7 yearsPosted 20.7 years ago

Interventions

Self Managementbehavioral

Two 1.5-hour in-person sessions and 6 10-15-minute telephone calls delivered by a dental hygienist, trained and supervised by a clinical psychologist. Structured, manual-based treatment based on standard cognitive-behavioral pain therapies and self-management interventions for chronic TMD pain. Sessions included education about the biopsychosocial model of chronic pain, TMD etiology and treatments, and the rationale for self-management; relaxation and stress management training; discussion of the role of stress and emotions as potential factors exacerbating and maintaining TMD symptoms; instruction and practice in self-monitoring of symptoms to identify factors that might be helpful to modify through self-care methods; practice of dentist-prescribed self-care treatments; and discussion of strategies to maintain gains and prevent relapse.

Targeted Self Managementbehavioral

Self management as described above. However, the intervention also included education about the potential effects of hormones on TMD pain, instructions to monitor the association of pain and other symptoms with menstrual cycle changes, and planning for times in participants' menstrual cycles when symptoms might increase. Participant contacts were timed according to each participant's menstrual cycle.

20 mcg ethinyl estradiol and 100 mcg levonorgestreldrug

Combination pill (20 mcg ethinyl estradiol and 100 mcg levonorgestrel) taken daily for 6 months.