CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 92 enrolled
Drug / intervention
radiation therapyradiation
Likely dose
Not stated in record
Key inclusion· 9
  • ✓Histologically confirmed low-grade glioma (JPA, diffuse astrocytoma, oligoastrocytoma, oligodendroglioma, or NOS); chiasmatic lesions with contiguous extension eligible without histology
  • ✓Progressive nonresectable disease, less than gross total resection (if symptomatic or high progression risk), or biopsy-only status
  • ✓Age 3-20 years
  • ✓ECOG 0-2, OR Karnofsky 50-100% (>16 years), OR Lansky 50-100% (≤16 years)
Key exclusion· 7
  • ✕Type-1 neurofibromatosis
  • ✕Evidence of leptomeningeal dissemination
  • ✕Prior radiotherapy
  • ✕Status epilepticus, coma, or requiring assisted ventilation prior to study entry

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00238264
NCT00238264Phase 2Completed
CompareCT.gov

A Phase II Study of Conformal Radiotherapy In Patients With Low-Grade Gliomas

Children's Oncology Group·interventional·Posted Oct 13, 2005·Updated Aug 7, 2019

In Brief

A Phase 2 clinical trial evaluating radiation therapy for Brain Tumor and Central Nervous System Tumor. Completed, enrolled 92 participants across 145 sites in 6 countries.

Detailed Summary

RATIONALE: Specialized radiation therapy that delivers radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. PURPOSE: This phase II trial is studying how well radiation therapy works in treating young patients with gliomas.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsBrain Tumor, Central Nervous System Tumor
CountriesAustralia, Canada, New Zealand, Puerto Rico, Switzerland, United States
CollaboratorsNational Cancer Institute (NCI)

Timeline

Phase 2CompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedOct 13, 2005
Enrollment StartNov 1, 2006
Primary CompletionDec 30, 2013
Study CompletionDec 31, 2018
TodayJul 2, 2026
Enrollment to primary: 7.2 yearsPosted 20.7 years ago

Interventions

radiation therapyradiation

Undergo 3D-CRT Undergo proton radiation therapy Undergo IMRT