At a glance
ClinicalIndex Comparison RecordN/ACompleted· 43 enrolled
Drug / intervention
Sertralinedrug
Likely dose
Sertraline 25 mg daily, titrated up to maximum 200 mg dailyAI-extracted
Key inclusion· 4
- ✓DSM-IV diagnosis of major depressive disorder
- ✓Hamilton Depression Scale (17-item) score of 18 or higher
- ✓Must speak English
- ✓Women must be post-menopausal
Key exclusion· 5
- ✕Current or previous psychiatric disorder other than MDD
- ✕Current unstable medical condition
- ✕Pacemaker or metal implant (MRI contraindication)
- ✕History of alcohol or drug dependence or abuse within the past year
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Nuclear Magnetic Resonance Imaging Study of Treatment With Sertraline in Geriatric Depression
In Brief
A clinical study evaluating Sertraline for Major Depressive Disorder. Completed, enrolled 43 participants across 1 site.
Detailed Summary
The purpose of this study was to use Magnetic Resonance Images to further our understanding of predictors and markers of treatment response and non-response in geriatric depression. We hypothesized that concentrations of high energy metabolites would be lower in depressed elderly compared to non-depressed.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMajor Depressive Disorder
CountriesUnited States
Timeline
N/ACompletedFinished
20052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
Enrollment StartNov 2004
First PostedOct 2005
Primary CompletionAug 2008
TodayJul 2026
First PostedOct 28, 2005
Enrollment StartNov 1, 2004
Primary CompletionAug 1, 2008
TodayJul 2, 2026
Enrollment to primary: 3.8 yearsPosted 20.7 years ago
Interventions
Sertralinedrug
Oral Sertraline Dosage started at 25 mg a day, with increases up to maximum dosage strength of 200 mg a day. Duration of treatment was 12 weeks.