At a glance
ClinicalIndex Comparison Record- ✓Clinical diagnosis of schizophrenia or schizoaffective disorder
- ✓Age 18–65 years
- ✓Stable medication for at least 30 days prior to enrollment
- ✓At least 30 days since last hospitalization
- ✕Current substance abuse
- ✕Comorbid neurological disease
- ✕History of traumatic brain injury
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
The Effects of Cognitive Rehabilitation on Function in Schizophrenia
In Brief
A clinical study evaluating Cognitive Rehabilitation Therapy (CRT) + Skill Training (SDG), Individual Computer Based Cognitive Rehabilitation (ICBCR) and Skills Training (SDG), and 1 other intervention for Cognitive Impairment and Schizophrenia. Completed, enrolled 59 participants across 1 site.
Detailed Summary
The study will investigate the viability of two cognitive rehabilitation strategies to improve functional outcomes for people with schizophrenia. Many people with schizophrenia experience impairments in cognitive function which limit their abilities. These impairments have been shown to precede the onset of illness and represent a vulnerability factor which is exacerbated by emerging psychotic symptoms. These impairments affect a range of functional domains including symptom severity, work function, symptom management, treatment, and overall quality of life. Recognizing the link between cognitive impairment and function, a few clinicals and researchers have attempted to remediate cognitive impairments by providing cognitive retraining programs similar to those used in traumatic brain injured patients or adaptive skills training. Cognitive retraining involves repetitive exercises to increase elemental cognitive functions including memory, attention, psychomotor speed, planning, and cognitive flexibility. Adaptive skill training involves didactic group exercises in social skills, activities of daily living, and symptom management. Each approach has demonstrated some rehabilitation benefits. This study will investigate the effectiveness of a combination of these two approaches on outcomes in schizophrenia.
Study Details
Timeline
Interventions
CRT is a one on one cognitive skills training and Skill training is a group intervention to develop concrete skills of daily living.
ICBCR is a computerized cognitive skills training program and Skill training is a group intervention to develop concrete skills of daily living.
Skill training is a group intervention to develop concrete skills of daily living. This is augmented with the opportunity to receive up to 5 hours of individual staff contact.