At a glance

ClinicalIndex Comparison Record

N/ACompleted· 30 enrolled

Drug / intervention

1.25 mg enalaprilat IV +1 moredrug

Likely dose

1.25 mg enalaprilat IVfrom record

Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00248807

NCT00248807N/ACompleted

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Systemic Hemodynamics and Cerebral Blood Flow in Persons With Tetraplegia

VA Office of Research and Development·interventional·Posted Nov 4, 2005·Updated Feb 25, 2025

In Brief

A clinical study evaluating 1.25 mg enalaprilat IV and Head up tilt (HUT) for Orthostatic Hypotension and Spinal Cord Injuries. Completed, enrolled 30 participants across 1 site.

Detailed Summary

The purpose of this study is to determine how blood pressure and blood flow are controlled during head-up tilt in a semi-upright position. In this investigation we are studying blood pressure and blood flow to the brain, with and without a medication which lowers blood pressure (Vasotec). We will determine how persons with a spinal cord injury are able to maintain blood flow to the brain (not get dizzy) as they assume a more upright position and their blood pressure decreases.

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsOrthostatic Hypotension, Spinal Cord Injuries

CountriesUnited States

Collaborators--

Timeline

N/ACompletedFinished

2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027

Enrollment StartOct 2005

First PostedNov 2005

Primary CompletionMay 2009

Study CompletionApr 2012

TodayJul 2026

First PostedNov 4, 2005

Enrollment StartOct 1, 2005

Primary CompletionMay 1, 2009

Study CompletionApr 1, 2012

TodayJul 2, 2026

Enrollment to primary: 3.6 yearsPosted 20.7 years ago

Interventions

1.25 mg enalaprilat IVdrug

an angiotensin converting enzyme (ACE) inhibitor given to lower blood pressure (BP) and measure cerebral blood flow (CBF)

Head up tilt (HUT)other

45 degree head-up tilt to lower blood pressure and measure cerebral blood flow.