At a glance
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Oral Prednisolone Dosing in Children Hospitalized With Asthma
In Brief
A Phase 4 clinical trial evaluating Prednisolone high dose and Prednisolone lower dose for Asthma. Completed, enrolled 152 participants across 1 site.
Detailed Summary
This study hopes to determine the appropriate oral steroid dose for treating children hospitalized with asthma exacerbations. Practice guidelines from different countries recommend a wide range of doses, and the doses used in actual practice vary widely. There is no data on what is the most appropriate dose of prednisone (or equivalent) in this situation. We will be looking at the dose recommended by the National Asthma Education and Prevention Program guidelines, which are published by the National Heart, Lung, and Blood Institute, as compared with a lower dose which is commonly used in practice. We hypothesize that the lower dose will be no worse than the higher dose as determined primarily by duration of hospitalization.
Study Details
Timeline
Interventions
4 mg/kg/day orally divided every 6 hours (maximum 30 mg per dose)
2 mg/kg/day orally divided q 12 (maximum 30mg/dose) alternating with placebo