At a glance
ClinicalIndex Comparison Record- ✓Age greater than 18 years
- ✓Successful electrical or chemical cardioversion within previous 2 weeks
- ✓More than 2 episodes of symptomatic AF in the previous 6 months
- ✕Currently on PAP therapy
- ✕Moderate to severe pulmonary disease
- ✕History of cerebrovascular accident, transient ischemic attack, neuromuscular disease, or diaphragmatic paralysis
- ✕Severe cardiac disease including LVEF <40% or greater than mild to moderate valvular disease
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Randomized Trial of Positive Airway Pressure Therapy In Atrial Fibrillation Recurrence In Sleep Apnea
In Brief
A clinical study evaluating Adaptive Servo-Ventilation and Usual Care for Sleep Apnea and Atrial Fibrillation. Completed, enrolled 25 participants across 1 site.
Detailed Summary
This randomized, controlled trial is designed to test whether treatment of sleep disordered breathing (SDB) with positive airway pressure (PAP) therapy alters the natural history of atrial fibrillation (AF). Patients with recent AF who are now in sinus rhythm, and found to have SDB (obstructive and/or central sleep apnea) by formal sleep study but without complaints of daytime sleepiness, are randomized to PAP therapy to eradicate SDB or to usual care (medical management as prescribed by the patient's cardiologist).
Study Details
Timeline
Interventions
Adaptive Servo-Ventilation provides positive expiratory airway pressure and inspiratory pressure support, which is servocontrolled based on the detection of central sleep apnea.
Subjects randomized to this arm received medical management as prescribed by their cardiologist.