At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Fractional Flow Reserve Versus Angiography for Multivessel Evaluation (F.A.M.E.)
In Brief
A clinical study evaluating Fractional flow reserve and Angio-guided PCI for Coronary Arteriosclerosis. Completed, enrolled 1,005 participants across 2 sites in 2 countries.
Detailed Summary
In this multicenter, international study we are evaluating two approaches to determine which coronary artery narrowings require stent placement in patients with multivessel coronary artery disease. Patients will be randomized to an angiographic strategy, where only coronary angiography is used to determine which lesions to stent or to a pressure wire strategy where fractional flow reserve, an index measured with the pressure wire, will be used to determine which lesions to stent. The primary outcome will be major adverse cardiac events at 1 year. A secondary outcome will be cost-effectiveness.