At a glance
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Treatment of Childhood Nasopharyngeal Carcinoma With Neoadjuvant Chemotherapy and Concomitant Chemoradiotherapy: A Groupwide Phase III Study
In Brief
A Phase 3 clinical trial evaluating Amifostine, Cisplatin, and 3 other interventions for Stage I Nasopharyngeal Keratinizing Squamous Cell Carcinoma AJCC v7 and 7 related conditions. Completed, enrolled 111 participants across 109 sites in 3 countries.
Detailed Summary
This phase III trial is studying how well radiation therapy, amifostine, and chemotherapy work in treating young patients with newly diagnosed nasopharyngeal cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. Drugs, such as amifostine, may protect normal cells from the side effects of radiation therapy. Drugs used in chemotherapy, such as cisplatin and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving radiation therapy together with amifostine and chemotherapy may kill more tumor cells.
Study Details
Timeline
Interventions
Given subcutaneously
Given IV
Given IV
Correlative studies
Undergo radiotherapy