CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 849 enrolled
Drug / intervention
chlorhexidine-alcohol +1 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00290290
NCT00290290Phase 3Completed
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Chlorhexidine-Alcohol Versus Povidone-Iodine for Surgical-Site Antisepsis:A Prospective, Randomized, Multicenter Clinical Trial

Baylor College of Medicine·interventional·Posted Feb 13, 2006·Updated Sep 18, 2014

In Brief

A Phase 3 clinical trial evaluating chlorhexidine-alcohol and Povidone-Iodine for Postoperative Wound Infection. Completed, enrolled 849 participants across 6 sites.

Detailed Summary

Most cases of infection of clean-contaminated wounds (wounds without gross spillage of organisms from the gastrointestinal tract) are thought to originate from the skin. Therefore, it is conceivable that application of an optimal antiseptic agent can reduce the rate of surgical wound infections. This trial is to compare the impact of disinfecting the skin with Chloraprep (2%chlorhexidine and 70% isopropyl alcohol) vs. Betadine on the rates of infection of clean-contaminated surgical wounds. The study will also assess the occurrence of adverse effects on the skin from either antiseptic agent and the cost-savings associated with the use of Chloraprep vs Betadine.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsPostoperative Wound Infection
CountriesUnited States
CollaboratorsMichael E. DeBakey VA Medical Center, Medical College of Wisconsin, US Department of Veterans Affairs

Timeline

Phase 3CompletedFinished
200420052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedFeb 13, 2006
Enrollment StartSep 1, 2003
Primary CompletionMay 1, 2008
TodayJul 2, 2026
Enrollment to primary: 4.7 yearsPosted 20.4 years ago

Interventions

chlorhexidine-alcoholdrug

Preoperative skin preparation with scrub and paint technique

Povidone-Iodinedrug

preoperative skin preparation with scrub and paint technique