At a glance
ClinicalIndex Comparison Record- ✓Persistent atrial fibrillation
- ✓NYHA class II, III, or IV chronic heart failure despite optimal medical therapy for at least 3 months
- ✓Left ventricular ejection fraction <35% measured by radionuclide ventriculography
- ✓CHF secondary to ischaemic or non-ischaemic aetiology
- ✕QRS duration >150 ms, or QRS 120-150 ms with evidence of mechanical cardiac dysynchrony
- ✕MRI-incompatible metallic (ferrous) prosthesis
- ✕Primary valvular disease as a cause of CHF
- ✕Reversible causes of CHF
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Radiofrequency Ablation for Atrial Fibrillation in Advanced Chronic Heart Failure
In Brief
A clinical study evaluating radiofrequency ablation, ACE inhibitor - ramipril, enalapril, captopril, perindopril, lisinopril, and 2 other interventions for Chronic Heart Failure and Atrial Fibrillation. Completed, enrolled 41 participants across 1 site.
Detailed Summary
Heart failure is a condition that occurs when the heart muscle weakens and no longer contracts normally. Half of these patients have an irregularity of heart rhythm called atrial fibrillation (AF). Patients with both heart failure and AF spend more time in hospital, and die earlier than those with heart failure alone. AF is difficult to treat with conventional methods in patients with heart failure. Radiofrequency ablation is a new technique used to cure AF. The investigators aim to establish if radiofrequency ablation for atrial fibrillation in patients with advanced heart failure can result in marked improvement in the function of the heart.
Study Details
Timeline
Interventions
isolation of the pulmonary veins with radiofrequency ablation (RFA)
Evidence based treatment for heart failure. Dose and type will depend on patient tolerability.
Evidence based treatment for heart failure. Dose and type will depend on patient tolerance.
Evidence based treatment for heart failure. Dose and type will depend on patient to treatment.