At a glance
ClinicalIndex Comparison RecordPhase 3Completed· 126 enrolled
Drug / intervention
prednisone alone +1 moredrug
Likely dose
prednisone alone 10mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Multi-Center, Single-Blind, Randomized Study Comparing Thymectomy to No Thymectomy in Non-Thymomatous Myasthenia Gravis (MG) Patients Receiving Prednisone
In Brief
A Phase 3 clinical trial evaluating thymectomy plus prednisone and prednisone alone for Myasthenia Gravis. Completed, enrolled 126 participants across 70 sites in 18 countries.
Detailed Summary
The purpose of this trial is to determine if thymectomy combined with prednisone therapy is more beneficial in treating non-thymomatous myasthenia gravis than prednisone therapy alone.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsMyasthenia Gravis
CountriesArgentina, Australia, Brazil, Canada, Chile, Germany, Italy, Japan, Mexico, Netherlands, Poland, Portugal, South Africa, Spain, Taiwan, Thailand, United Kingdom, United States
Timeline
Phase 3CompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedFeb 2006
Enrollment StartJun 2006
Primary CompletionNov 2015
Study CompletionDec 2015
TodayJul 2026
First PostedFeb 22, 2006
Enrollment StartJun 1, 2006
Primary CompletionNov 1, 2015
Study CompletionDec 1, 2015
TodayJul 2, 2026
Enrollment to primary: 9.4 yearsPosted 20.4 years ago
Interventions
thymectomy plus prednisoneprocedure
The thymectomy will be performed as soon as possible after randomization.
prednisone alonedrug
Prednisone regimen will be every other day, starting at 10mg. The dose will increase by 10mg every 2 days to a target dose.