CI

At a glance

ClinicalIndex Comparison Record
Phase 3Completed· 101 enrolled
Drug / intervention
Sertraline +2 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00302068
NCT00302068Phase 3Completed
CompareCT.gov

Understanding the Prognostic Benefits of Exercise and Anti-depressant Therapy (UPBEAT)

Duke University·interventional·Posted Mar 13, 2006·Updated Jun 29, 2015

In Brief

A Phase 3 clinical trial evaluating Supervised Aerobic Exercise, Sertraline, and 1 other intervention for Depression and Heart Diseases. Completed, enrolled 101 participants across 1 site.

Detailed Summary

Some individuals with coronary heart disease (CHD) suffer from depression and use antidepressant medications to reduce symptoms. However, preliminary research has shown that exercise may be a more effective way to treat depression in these individuals. The purpose of this study is to evaluate the effects of exercise in reducing depression and improving heart function in individuals with CHD.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsDepression, Heart Diseases
CountriesUnited States
CollaboratorsPfizer

Timeline

Phase 3CompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedMar 13, 2006
Enrollment StartJul 1, 2006
Primary CompletionJul 1, 2011
Study CompletionDec 1, 2011
TodayJul 2, 2026
Enrollment to primary: 5 yearsPosted 20.3 years ago

Interventions

Supervised Aerobic Exercisebehavioral

Supervised aerobic exercise, three times per week, for 16 weeks.

Sertralinedrug

Sertraline (Zoloft), daily, for 16 weeks.

Placebo Pill.drug

Placebo pill, daily, for 16 weeks.