At a glance
ClinicalIndex Comparison Record- ✓Auditory hallucinations occurring at least 5 times per day on average
- ✓Diagnosis of schizophrenia or schizoaffective disorder
- ✕Pregnant
- ✕History of non-drug-induced or non-alcohol-withdrawal seizure
- ✕Drug or alcohol abuse within 6 weeks of study entry
- ✕Antipsychotic dose changes within 4 weeks of study entry
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Transcranial Magnetic Stimulation Guided by Neuroimaging for Patients With Persistent "Voices"
In Brief
A Phase 2 clinical trial evaluating 1-hertz Repetitive Transcranial Magnetic Stimulation and Active 1-Hertz Repetitive transcranial magnetic stimulation for Schizophrenia and Hallucinations. Completed, enrolled 85 participants across 1 site.
Detailed Summary
This study will determine the efficacy of MRI-guided transcranial magnetic stimulation (TMS)in reducing "voices" and other symptoms experienced by people with schizophrenia and schizoaffective disorder. In addition, the study will determine duration of improvement obtained during the course of trial participation via on-going monthly contact with study participants for up to 1 year after the trial.
Study Details
Timeline
Interventions
Sham stimulation given to Wernicke's area or a right homologous area for 16 minutes per day x 5 days for week I, the same for week II with switch from right to left or left to right, and 5 more stimulation sessions (16 minutes per session) to the side producing greater benefit for week III.
Active stimulation given to Wernicke's area or a right homologous area for 16 minutes per day x 5 days for week I, the same for week II with switch from right to left or left to right, and 5 more stimulation sessions (16 minutes per session) to the side producing greater benefit for week III.