CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 506 enrolled
Drug / intervention
Albuterol +1 moredrug
Likely dose
Albuterol 5 mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00310401
NCT00310401Phase 2Completed
CompareCT.gov

The Effect of Nebulized Albuterol on Donor Oxygenation

Vanderbilt University Medical Center·interventional·Posted Apr 3, 2006·Updated Mar 16, 2018

In Brief

A Phase 2 clinical trial evaluating Albuterol and Saline for Brain Death and 2 related conditions. Completed, enrolled 506 participants across 1 site.

Detailed Summary

The purpose of this study is to test the effectiveness of albuterol versus placebo with the following specific aims: a) Treatment of brain dead organ donors with albuterol will reduce pulmonary edema, improve donor oxygenation, and increase the number of lungs available for transplantation, b) Developing a blood test to predict the development of primary graft dysfunction in lung transplant recipients, and c) treating brain dead organ donors with albuterol will decrease markers of primary graft dysfunction and lead to improved lung transplant recipient outcomes and to higher rates of lungs suitable for transplantation.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsBrain Death, Organ Donor, Pulmonary Edema
CountriesUnited States
CollaboratorsCalifornia Transplant Donor Network, University of California, San Francisco

Timeline

Phase 2CompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedApr 3, 2006
Enrollment StartApr 1, 2007
Primary CompletionMay 1, 2011
Study CompletionJun 1, 2011
TodayJul 2, 2026
Enrollment to primary: 4.1 yearsPosted 20.2 years ago

Interventions

Albuteroldrug

5 mg nebulized q4h

Salinedrug

1.0 cc diluted with saline in identical fashion to study drug and administered by nebulizer every 4 hours