At a glance
ClinicalIndex Comparison Record- ✓Weight stable with indication for weight loss per NIH guidelines
- ✓Short physical performance battery score between 3 and 10 (indicating functional limitation)
- ✕Diabetes mellitus
- ✕Weight exceeding 136 kg
- ✕Medical condition that limits exercise participation
- ✕Congestive heart failure
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Optimizing Body Composition for Function in Older Adults (OPTIMA) - A Pepper Pilot Study
In Brief
A Phase 4 clinical trial evaluating Pioglitazone, Resistance exercise training to maximize muscle power, and 2 other interventions for Obesity and Overweight With Indications for Weight Loss. Completed, enrolled 88 participants across 1 site.
Detailed Summary
The purpose of this pilot study is to compare two strategies intended to improve the health of overweight older adults by improving body composition. One strategy, resistance training, is designed to preserve skeletal muscle mass. The other strategy, the use of a PPAR-γ agonist, is designed to enhance the loss of fat from visceral and skeletal depots. These strategies will be used in conjunction with a hypocaloric diet and will be compared to a hypocaloric diet alone to determine if either of these strategies are superior in reducing visceral fat and preserving muscle mass.