At a glance
ClinicalIndex Comparison Record- ✓Age 7 to 12 years old (inclusive)
- ✓Amblyopia associated with strabismus, anisometropia, or both
- ✓Visual acuity in the amblyopic eye 19 to 71 letters on E-ETDRS (20/40 to 20/400 inclusive)
- ✓Visual acuity in the sound eye 79 letters or better on E-ETDRS (20/25 or better)
- ✕Amblyopia treatment (other than spectacles) in the last 6 months
- ✕Myopia greater than −0.25D spherical equivalent in either eye
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Randomized Trial Comparing Patching Versus Atropine for Amblyopia in 7 to < 13 Year Olds
In Brief
A Phase 3 clinical trial evaluating Atropine, Patching, and 1 other intervention for Amblyopia. Completed, enrolled 233 participants across 2 sites.
Detailed Summary
The purpose of this study is: * To compare the effectiveness of weekend atropine plus near activities and daily patching plus near activities for moderate amblyopia (20/40 to 20/100) and severe amblyopia (20/125 to 20/400) in improving vision in the amblyopic eye of 7 to \<13 year olds. * To determine the maximum improvement in vision of the amblyopic eye with each treatment. * To determine whether amblyopia is associated with structural abnormalities of optic nerve fiber layer.
Study Details
Timeline
Interventions
Atropine 1% each weekend day in the sound eye
Patching 2 hours per day
near visual activities for at least one hour per day