At a glance
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Combined Pharmaco/Behavior Therapy in Adolescent Smokers
In Brief
A Phase 2 clinical trial evaluating Bupropion SR, Contingency Management, and 1 other intervention for Nicotine Dependence and Nicotine Use Disorder. Completed, enrolled 134 participants across 1 site.
Detailed Summary
In the current proposal, we intend to study the efficacy of bupropion SR with or without combined contingency management (CM) among adolescent cigarette smokers. The proposed study will test not only medication (bupropion SR), but also combination of medication and CM in potentially improving smoking cessation outcomes AND retention of adolescent smokers in the study. Hypothesis to be tested: Bupropion SR treatment will increase abstinence from cigarette smoking (as measured by urine cotinine and continuous abstinence) in adolescent smokers as compared to treatment with placebo only. Hypothesis to be tested: Adolescent smokers treated with combined bupropion SR + contingency management (CM) treatment will have increased retention and increased abstinence rates when compared to bupropion SR alone or CM + placebo treated groups (as measured by decreased drop-out of participants, urine cotinine and continuous abstinence). Hypothesis to be tested: CM will increase the abstinence from cigarette smoking (as measured by urine cotinine and continuous abstinence) in adolescent smokers as compared to treatment with placebo only.
Study Details
Timeline
Interventions
Bupropion SR, with goal dose 300 mg/day, for 6 weeks of active treatment
Contingency Management provided at twice-weekly visits during the 6-week active treatment. Escalating schedule, with resets, reinforcing smoking abstinence.
Placebo, matched in appearance to Bupropion SR, for 6 weeks of treatment