At a glance
ClinicalIndex Comparison Record- ✓Healthy subjects without diabetes or glucose intolerance
- ✕Diabetes or impaired glucose tolerance
- ✕Peripheral vascular disease
- ✕Pulmonary disease
- ✕Clinically significant hepatic or renal disease
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Mechanisms of Insulin Resistance in Humans
In Brief
An observational study evaluating 20% Intralipid for Inflammation and Insulin Resistance. Completed, enrolled 25 participants across 1 site.
Detailed Summary
The Objectives of the study are to: (1)compare the inflammatory response and insulin resistance in skeletal muscles during a systemic infusion of lipid with that during a local infusion of lipid into the femoral artery. which would cause minimal or no systemic hyperlipidemia but local plasma free fatty acid (FFA) concentrations similar to those during the systemic lipid infusion, and (2) determine the inflammatory response and insulin resistance in skeletal muscle during an infusion of lipid into the femoral artery as described above after NF-KB inhibition by high dose salicylate treatment in humans.
Study Details
Timeline
Interventions
lipid infusion