At a glance
ClinicalIndex Comparison RecordPhase 4Completed· 1,504 enrolled
Drug / intervention
nicotine patch +5 moredrug
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Pharmacotherapies: Efficacy, Mechanisms and Algorithms
In Brief
A Phase 4 clinical trial evaluating nicotine patch, nicotine lozenge, and 4 other interventions for Nicotine Dependence. Completed, enrolled 1,504 participants across 2 sites.
Detailed Summary
The proposed work will advance the understanding and effectiveness of tobacco dependence treatment and result in more smokers quitting successfully.
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsNicotine Dependence
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)
Timeline
Phase 4CompletedFinished
20052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
Enrollment StartSep 2004
First PostedJun 2006
Primary CompletionAug 2010
TodayJul 2026
First PostedJun 2, 2006
Enrollment StartSep 1, 2004
Primary CompletionAug 1, 2010
TodayJul 2, 2026
Enrollment to primary: 5.9 yearsPosted 20.1 years ago
Interventions
nicotine patchdrug
used according to FDA package label
nicotine lozengedrug
used according to FDA-approved package directions
nicotine patch + nicotine lozengedrug
dosage of both according to FDA-approved dosing schedule
bupropiondrug
dosage according to FDA-approved instructions
bupropion + lozengedrug
dosage according to FDA approved standard instructions
placebodrug
dosage same as active drug conditions