At a glance
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A Study of Unilateral Retinoblastoma With and Without Histopathologic High-Risk Features and the Role of Adjuvant Chemotherapy
In Brief
A Phase 3 clinical trial evaluating liposomal vincristine sulfate, carboplatin, and 1 other intervention for Intraocular Retinoblastoma. Completed, enrolled 331 participants across 56 sites in 5 countries.
Detailed Summary
This phase III trial is studying vincristine, carboplatin, and etoposide to see how well they work compared to observation only in treating patients who have undergone surgery for newly diagnosed retinoblastoma. Drugs used in chemotherapy, such as vincristine, carboplatin, and etoposide, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) after surgery may kill any tumor cells that remain after surgery. Sometimes, after surgery, no additional treatment is needed for the tumor until it progresses. In this case, observation may be sufficient.
Study Details
Timeline
Interventions
Given IV
Given IV
Given IV