At a glance
ClinicalIndex Comparison RecordStandardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
A Randomized, Double Blind, Parallel-group Study Of Cardiovascular Safety In Osteoarthritis Or Rheumatoid Arthritis Patients With Or At High Risk For Cardiovascular Disease Comparing Celecoxib With Naproxen And Ibuprofen
In Brief
A Phase 4 clinical trial evaluating celecoxib, Ibuprofen, and 1 other intervention for Arthritis, Rheumatoid. Completed, enrolled 24,081 participants across 1,066 sites in 13 countries.
Detailed Summary
To answer the question of overall benefit: risk of celecoxib when compared to two most commonly prescribe traditional (non-selective) nonsteroidal anti-inflammatory drugs (NSAIDs) in the treatment of arthritis pain. For this purpose, patients with osteoarthritis or rheumatoid arthritis with or at risk of developing cardiovascular disease will be recruited. The cardiovascular, gastrointestinal and renal safety and symptomatic benefit in each treatment group will be assessed accordingly.
Study Details
Timeline
Interventions
100 to 200 mg twice daily, taken by mouth
ibuprofen 600 mg to 800 mg three times daily, taken by mouth
naproxen 375mg to 500 mg twice daily, taken by mouth