At a glance
ClinicalIndex Comparison RecordPhase 1Completed· 181 enrolled
Drug / intervention
disulfiram +3 moredrug
Likely dose
disulfiram 250mgfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.
Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.
Maximizing the Efficacy of Cognitive Behavioral Therapy With Medication and Contingency Management
In Brief
A Phase 1 clinical trial evaluating disulfiram, Placebo, and 2 other interventions for Cocaine Abuse. Completed, enrolled 181 participants across 1 site.
Detailed Summary
This is a study of four treatments for chronic cocaine use and may help study participants to control their drug use. All participants will receive weekly individual cognitive behavioral therapy (CBT).
Study Details
Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsCocaine Abuse
CountriesUnited States
CollaboratorsNational Institute on Drug Abuse (NIDA)
Timeline
Phase 1CompletedFinished
20052006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
Enrollment StartApr 2005
First PostedJul 2006
Primary CompletionDec 2010
TodayJul 2026
First PostedJul 11, 2006
Enrollment StartApr 1, 2005
Primary CompletionDec 1, 2010
TodayJul 2, 2026
Enrollment to primary: 5.7 yearsPosted 20.0 years ago
Interventions
disulfiramdrug
250mg per day of Disulfiram plus CBT
Placebodrug
Placebo plus CBT
Placebo plus Contingency Managementbehavioral
Placebo plus Contingency Management for cocaine abstinence and medication compliance in addition to CBT
Disulfiram plus Contingency Managementdrug
250mg of Disulfiram plus Contingency Management for cocaine abstinence and medication compliance plus CBT.