At a glance

ClinicalIndex Comparison Record

Phase 3Completed· 42 enrolled

Drug / intervention

Doxycycline and Rifampin +2 moredrug

Likely dose

Doxycycline and Rifampin 100mgfrom record

Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00351273

NCT00351273Phase 3Completed

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Phase 3 Trial to Assess the Efficacy of Long-term (6 Months) Combination Antibiotics as a Treatment for Chlamydia-induced Reactive Arthritis

University of South Florida·interventional·Posted Jul 12, 2006·Updated Nov 13, 2018

In Brief

A Phase 3 clinical trial evaluating Doxycycline and Rifampin, Azithromycin and Rifampin, and 1 other intervention for Arthritis, Reactive and Reiter Disease. Completed, enrolled 42 participants across 3 sites in 2 countries.

Detailed Summary

Reactive arthritis, also known as Reiter's syndrome, is a form of arthritis that occurs as a reaction to an infection elsewhere in the body. It is characterized by inflammation of the joints, tendons, urogenital tract, and eyes. Pain and swelling in the knees, ankles, and feet are common. This study will determine the effectiveness of antibiotic therapy in treating people with chlamydia-induced reactive arthritis that has lasted for more than 6 months.

Study Details

Study Typeinterventional

Allocation--

Masking--

Primary Purpose--

ConditionsArthritis, Reactive, Reiter Disease

CountriesCanada, United States

CollaboratorsNational Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Timeline

Phase 3CompletedFinished

2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027

Enrollment StartMay 2006

First PostedJul 2006

Primary CompletionSep 2008

TodayJul 2026

First PostedJul 12, 2006

Enrollment StartMay 1, 2006

Primary CompletionSep 1, 2008

TodayJul 2, 2026

Enrollment to primary: 2.3 yearsPosted 20.0 years ago

Interventions

Doxycycline and Rifampindrug

doxycycline 100mg daily; rifampin 300mg daily (both for 6 months)

Azithromycin and Rifampindrug

Azithromycin 500mg daily for 5 days and then twice weekly; Rifampin 300mg daily (both for 6 months)

Placebodrug

Methylcellulose