CI

At a glance

ClinicalIndex Comparison Record
Phase 2Completed· 11 enrolled
Drug / intervention
anastrozole +3 moredrug
Likely dose
anastrozole 1 milligramfrom record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00354640
NCT00354640Phase 2Completed
CompareCT.gov

A Trial Assessing the Effect of Simvastatin on the Pharmacokinetics of Anastrozole

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins·interventional·Posted Jul 20, 2006·Updated Jun 24, 2013

In Brief

A Phase 2 clinical trial evaluating anastrozole, simvastatin, and 2 other interventions for Breast Cancer. Completed, enrolled 11 participants across 1 site.

Detailed Summary

RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of simvastatin and anastrozole may stop cancer from forming, growing, or coming back in patients with invasive breast cancer, ductal carcinoma in situ, or a high risk of breast cancer. PURPOSE: This phase II trial is studying how well giving simvastatin together with anastrozole works in treating postmenopausal women with invasive breast cancer, ductal carcinoma in situ, or a high risk of breast cancer.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsBreast Cancer
CountriesUnited States
CollaboratorsNational Cancer Institute (NCI)

Timeline

Phase 2CompletedFinished
2006200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedJul 20, 2006
Enrollment StartJun 1, 2006
Primary CompletionOct 1, 2008
Study CompletionNov 1, 2011
TodayJul 2, 2026
Enrollment to primary: 2.3 yearsPosted 19.9 years ago

Interventions

anastrozoledrug

1 milligram tablet PO QD for 14 days

simvastatindrug

40 milligram tablet PO QD for 14 days

pharmacological studyother

laboratory analysis

adjuvant therapyprocedure

laboratory analysis