CI

At a glance

ClinicalIndex Comparison Record
Phase 4Completed· 511 enrolled
Drug / intervention
Dual chamber pacemekerdevice
Likely dose
Not stated in record
Structured eligibility isn't available for this trial yet — see the full criteria in the Eligibility tab below.

Standardized by ClinicalIndex from the ClinicalTrials.gov record · verify against the source.

Search/NCT00359203
NCT00359203Phase 4Completed
CompareCT.gov

ISSUE3: International Study on Syncope of Uncertain Etiology 3 Pacemaker Therapy for Patients With Asystolic Neurally-mediated Syncope

Medtronic Cardiac Rhythm and Heart Failure·interventional·Posted Aug 1, 2006·Updated Jul 18, 2025

In Brief

A Phase 4 clinical trial evaluating Dual chamber pacemeker for Syncope. Completed, enrolled 511 participants across 1 site.

Detailed Summary

ISSUE 3 is a multi-center, prospective, randomised controlled double-blind study aimed to assess the effectiveness of pacemaker therapy for prevention of asystolic neurally-mediated syncope.

Study Details

Study Typeinterventional
Allocation--
Masking--
Primary Purpose--
ConditionsSyncope
CountriesItaly
Collaborators--

Timeline

Phase 4CompletedFinished
200720082009201020112012201320142015201620172018201920202021202220232024202520262027
First PostedAug 1, 2006
Enrollment StartSep 1, 2006
Primary CompletionSep 1, 2011
Study CompletionNov 1, 2012
TodayJul 2, 2026
Enrollment to primary: 5 yearsPosted 19.9 years ago

Interventions

Dual chamber pacemekerdevice