At a glance
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A Placebo-Controlled Trial of D-Cycloserine and Exposure Therapy for Combat-PTSD
In Brief
A clinical study evaluating Exposure therapy, D-Cycloserine, and 1 other intervention for Combat Disorders and Stress Disorders, Post-Traumatic. Completed, enrolled 26 participants across 1 site.
Detailed Summary
The primary aim of this project is to examine whether administration of D-Cycloserine (DCS), a partial N-methyl-D-aspartate (NMDA) receptor agonist that has been shown to facilitate fear extinction, enhances the therapeutic benefit of exposure-based cognitive behavioral therapy (CBT) in OEF/OIF veterans with PTSD.
Study Details
Timeline
Interventions
A manualized form of treatment that involves vividly visualizing indexed trauma with the guidance of a therapist
A partial NMDA agonist that has been shown in human trials to facilitate and strengthen extinction with CBT.